WILMINGTON, MA — Below are 5 things to do in Wilmington on Monday, December 10, 2018:#1) WCTV Fundraiser at Red Heat TavernWant some good food while supporting a great cause? Wilmington Community Television (WCTV) is hosting a fundraiser at Red Heat Tavern (300 Lowell Street) from 4pm to 10pm. All you need to do is bring the flyer below (print it out or show it on your phone) and 10% of your check will go to WCTV. This is for dine-in or take-out. It’s an easy and delicious way to support the station.#2) Family Holiday SingalongThe Wilmington Memorial Library (175 Middlesex Avenue) is hosting a holiday sing-along on Monday, December 10 at 6:30pm! David Polansky, an award-winning singer, musician and composer, will present a repertoire of classic holiday songs and original compositions that will encompass Christmas, Hanukkah and Kwanzaa! All ages. Register HERE.#3) Wilmington Board of Selectmen MeetingThe Wilmington Board of Selectmen meets at 7pm in Town Hall’s Room 9. (Executive Session precedes the meeting at 6:30pm.) The North Wilmington Train Station, Butters Row Bridge Replacement, the Woburn Street/Lowell Street Intersection, Russell Disposal, and more are on the agenda. Read the full agenda HERE. The meeting is open to the public.#4) Wilmington Housing Authority Meeting MeetingThe Wilmington Housing Authority meets at 5pm in Deming Way’s Community Hall. The Capital Improvement Plan and Vacant Land With Development Potential are on the agenda. Read the full agenda HERE.#5) Wilmington Job Seekers Network MeetingThe Wilmington Memorial Library (175 Middlesex Avenue) is hosting a meeting of its networking group at 10am. Find out what the new tax code is all about and how it may affect you. Beth Logan is an Enrolled Agent with a tax practice and business consulting in Chelmsford. She teaches classes on taxes to laypersons and other Enrolled Agents. She is a nationally published author including articles and two books on taxes. She has an MBA from the University of Maryland and two engineering degrees. Register HERE.Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email firstname.lastname@example.org.Thank You To Our Sponsor:Share this:TwitterFacebookLike this:Like Loading… Related5 Things To Do In Wilmington On Monday, September 9, 2019In “5 Things To Do Today”5 Things To Do In Wilmington On Thursday, September 5, 2019In “5 Things To Do Today”5 Things To Do In Wilmington On Sunday, September 8, 2019In “5 Things To Do Today”
Prime minister Sheikh Hasina addresses the inauguration programme of a two-day Dhaka Meeting of the Global Commission on Adaptation in a hotel in Dhaka on Wednesday. Photo: BSSPrime minister Sheikh Hasina on Wednesday sought global leaders’ enhanced awareness about the climate change and their effective initiatives to negate its impacts.“I request all for their awareness and respective responsibility to fight the adverse impacts of climate change,” she said while inaugurating a two-day Dhaka Meeting of the Global Commission on Adaptation in a city hotel.The prime minister also urged the world community to put more emphasis on research and investment on this issue as the climate change is fast affecting agriculture, life and livelihood.Marshal Islands president Hilda C Heine, former United Nations Secretary General and incumbent Global Commission on Adaptation Chairman Ban Ki-moon and World Bank chief executive officer Kristalina Georgieva were present at the function.Speaking on the occasion, the three dignitaries highly praised prime minister Sheikh Hasina for her extraordinary leadership to lead the world to address the adverse impacts of climate change from the forefront.Hailing Bangladesh’s initiatives and strategies to fight the climate change impacts, Ban Ki-moon said, “Of Course we are here to learn from Bangladesh. When comes to adaptation, Bangladesh is the best teacher to learn about adaptation.”Wishing a complete success of the Dhaka Meeting of GCA, prime minister Sheikh Hasina said, “This is a great opportunity for us to demonstrate our own strategies to adapt to climate change, build resilience as well as offer to share our knowledge and experience with you.”“We are eagerly waiting to see the recommendations of the flagship report next September at the time of the climate change summit called by the secretary general of the United Nations where I, on behalf of Bangladesh and the Least Developed Countries (LDCs), have been invited to speak,” she said.Bangladesh is expecting to take advantage of the best adaptation practices, most cost-effective solutions and risk reduction with the help of the Global Commission on Adaptation, she said.The premier said that being a leading country of adaptation, Bangladesh deserves to have a Regional Adaption Centre in Dhaka.Highlighting her government’s frantic efforts to effectively fight the climate change, she said, “We are working relentlessly to overcome our vulnerabilities and create adaptation measures for the people. Over the last decade, we have spent on an average around US$ 1 billion annually for adapting to climate change impacts.”Furthermore, to achieve climate resilience, the government created a dedicated Climate Change Trust Fund in 2009 and so far, more than US$ 420 million have been allocated from own resources to the fund for both adaptation and mitigation programmes, she informed the meeting.“We have designed project titled ‘Bangladesh Delta Plan 2100’ for combating climate change,” the prime minister also said.Considering the adverse impacts of climate change, Sheikh Hasina said, her government is currently constructing more 378 Mujib Kellas, 3,868 multi-purpose cyclone shelters across the coastal districts and planning to build 1,650 more shelters gradually.She said, “Father of the nation Bangabandhu Sheikh Mujibur Rahman showed the path of climate adaptation by building 172 Mujib Kellas (cyclone shelters) in the coastal areas.”“We have taken initiatives to increase tree coverage from 22 per cent to 24 per cent in the next five years. So far Bangladesh has created 0.2 million hectares of coastal forests as shelterbelt to protect from tidal surges and calamities. Bangladesh is also successfully managing 601,700 hectares of Sundarbans Mangrove forest,” the prime minister said.Foreign minister AK Abdul Momen and environment, forest and climate change minister Md. Shahab Uddin also spoke on the occasion.Seeking more attention from the global community to repatriate Rohingyas quickly, the prime minister said, “It is the responsibility of the global community to do more to ensure their quick return to Myanmar as well as look after them while they remain in Bangladesh as we have shelter to 1.1 million evicted Rohingyas in Cox’s Bazar.”She also said that their presence in Cox’s Bazar makes the southeast coastal district of Bangladesh vulnerable.Prime minister Sheikh Hasina talks to Marshal Islands president Hilda C Heine (C) and former United Nations Secretary General and incumbent Global Commission on Adaptation Chairman Ban Ki-moon in a hotel in Dhaka on Wednesday. Photo: PIDThe prime minister said Bangladesh has engaged in creating resilient forests in offshore areas to protect forest dependent communities and habitats of important forest biodiversity.“Besides, our scientists and farmers invented stress tolerant rice cultivation technologies which produced good results. Floating garden – a low input -low cost resilient family farming production system in the wetlands of the south-central coastal districts is another good example,” she said.Household Silo (HHS) is another adaptation practice in Bangladesh to ensure food security in disaster prone areas, she added.“Bangladesh, being one of the most vulnerable countries to climate change, is also at the forefront of learning on how to tackle the adverse impacts of climate change,” the premier said.The prime minister said Bangabandhu Sheikh Mujibur Rahman initiated Cyclone Preparedness Program (CPP) in 1972 for effective cyclone preparedness in coastal areas and prepared 49,365 trained volunteers to this end.Referring to deaths in several catastrophic cyclone since 1970 which claimed around 1 million lives in Bangladesh, she said, “The impact of natural calamities have come down significantly due to the present government’s various timely and effective measures.”In this regard, she said at least 150,000 people died in the 1991 catastrophic cyclone, adding that Cyclone Sidr in 2007 caused deaths of more than 3,400 people.She also said Cyclone Aila hit southwest coast of Bangladesh in May 2009 claiming around 190 people while Cyclone Fani in May 2019 claimed less than 10 people.Referring to ADB’s climate and economics report for South Asia predicting that Bangladesh’s annual GDP loss will be 2 per cent, if temperature continues to rise at the current rate, Hasina said 19 coastal districts of the country will face consequence if the sea level rises.“Evidences suggest that Bangladesh has already 6 million climate migrants, a number that could more than double by 2050 due to changes in temperature, increased frequency and severity of floods, droughts, heat waves, cyclones and storm surges, sea level rise, and salinity intrusion,” she added.“These changes are seriously affecting agriculture, crops, livestock and fisheries and threatening the food security of Bangladesh. According to IPCC report AR4, rice production in Bangladesh could decline by 8 per cent and wheat by 32 per cent by 2050 due to climate change,” she continued.“In 2015 in Paris, we have been successful in creating a solid ground for a meaningful cooperation in combating climate change impacts. Like many others, we firmly believe that climate change is a global challenge and we have to resort to global solutions,” the prime minister said.The Paris Agreement is the most pragmatic and effective global deal towards the global solution, she added.
Just a few drinks in an evening may change how memories are formed at the fundamental, molecular level, a study suggests. One of the many challenges with battling alcohol addiction and other substance abuse disorders is the risk of relapse, even after progress towards recovery, said researchers from Brown University in the US. Even pesky fruit flies have a hankering for alcohol, and because the molecular signals involved in forming flies’ reward and avoidance memories are much the same as those in humans, they are a good model for study. Also Read – Add new books to your shelfThe study, published in the journal Neuron, in flies found that alcohol hijacks this memory formation pathway and changes the proteins expressed in the neurons, forming cravings. Researchers uncovered the molecular signalling pathways and changes in gene expression involved in making and maintaining reward memories. “One of the things I want to understand is why drugs of abuse can produce really rewarding memories when they’re actually neurotoxins,” said Karla Kaun, an assistant professor at Brown University. Also Read – Over 2 hours screen time daily will make your kids impulsiveLed by Emily Petruccelli, who is now an assistant professor at Southern Illinois University in the US, the team used genetic tools to selectively turn off key genes while training the flies where to find alcohol. This enabled them to see what proteins were required for this reward behaviour. One of the proteins responsible for the flies’ preference for alcohol is Notch, the researchers found. Notch is the first “domino” in a signalling pathway involved in embryo development, brain development and adult brain function in humans and all other animals. Molecular signalling pathways are not unlike a cascade of dominos – when the first domino falls (in this case, the biological molecule activates), it triggers more that trigger more and so on. One of the downstream dominos in the signalling pathway affected by alcohol is a gene called dopamine-2-like receptor, which makes a protein on neurons that recognises dopamine, the “feel-good” neurotransmitter. “The dopamine-2-like receptor is known to be involved in encoding whether a memory is pleasing or aversive,” Petruccelli said. Alcohol hijacks this conserved memory pathway to form cravings. In the case of the alcohol reward pathway studied, the signalling cascade didn’t turn the dopamine receptor gene on or off, or increase or decrease the amount of protein made, Kaun said. Instead, it had a subtler effect – it changed the version of the protein made by a single amino acid “letter” in an important area. “We don’t know what the biological consequences of that small change are, but one of the important findings from this study is that scientists need to look not only at which genes are being turned on and off, but which forms of each gene are getting turned on and off,” Kaun said. “We think these results are highly likely to translate to other forms of addiction, but nobody has investigated that,” she said. Kaun is working with John McGeary, assistant professor at Brown, to look at DNA samples from patients with alcohol abuse disorders to see if they have genetic polymorphisms in any of the craving-related genes discovered in flies. “If this works the same way in humans, one glass of wine is enough to activate the pathway, but it returns to normal within an hour,” Kaun said. “After three glasses, with an hour break in between, the pathway doesn’t return to normal after 24 hours. We think this persistence is likely what is changing the gene expression in memory circuits,” said Kaun. “Just something to keep in mind the next time you split a bottle of wine with a friend or spouse,” she said.
Enroll Now for Free This hands-on workshop will give you the tools to authentically connect with an increasingly skeptical online audience. Opinions expressed by Entrepreneur contributors are their own. April 30, 2018 Free Workshop | August 28: Get Better Engagement and Build Trust With Customers Now Running a company in the 21st century maymake you feel as if you’re living in a world of infinite possibilities: Technology is causing things to change rapidly in every industry, and there are so many different things you can try, to out-innovate your competitors.Related: 3 Ways to End Technology DistractionBut becoming too enamored with the endless possibilities can cause you to divert your focus from the critical functions of the organization.Striking a proper balance, therefore, between learning when to embrace new opportunities and sticking to what you know is actually fairly straightforward. You just have to pay attention to the evidence around you, understand what makes you successful and never take your eyes off your customers just to chase a fad.Trust your data to keep you on track.One of the best things you can do for your business is to institute a comprehensive policy for collecting, using and managing performance data. One of the biggest mistakes you can make is to spend the resources to do this, and then disregard your findings.According to a study from CEB summarized in the Harvard Business Review, companies still see a significant gap between collecting data and using it properly. Despite the widespread availability of data and the relative ease of gathering it, compared to what previously was the case, many businesses still struggle with employing analytics to aid in decision-making. Only 50 percent of senior leaders in the study were identified as being “data-savvy.”Related: 6 Ways to Master Distraction and Stay FocusedThe ability to be bold and take risks is important for any business leader. However, when you think you are on to the next great idea, and you refuse to listen to data that indicates otherwise, critical problems will likely arise.Experiment with new marketing channels slowly and carefully.Marketing in the digital age really is like holding a double-edged sword.On the one hand, there are more ways than ever to reach a captive audience of millions with personalized messaging. But it also seems like a new marketing medium pops up every few months. Just think of how few companies even considered marketing through Snapchat a couple of years ago. For business owners, trying to keep up with the latest platform can be a resource-intense distraction.It is important to follow the developments of new technology and try to reach customers through different marketing outlets, especially if your core customer base is made up of people who are likely to be using these platforms. However, it is unwise to divert too many dollars and staff hours away from your proven marketing channels in an effort to be on top of trends. Start gradually, at first, until you have a clear idea of what kind of results you can expect to achieve, and at what cost.Know your core competencies.One of the best ways to avoid getting distracted by all of the possibilities available to you is to understand what your company does exceptionally well, and funnel most of your energy into that. Then, allocate a small portion of your remaining resources toward piloting new projects and experimenting with novel campaigns.When GoPro decided to enter the drone market, the company shifted its focus and resources away from its core product, action cameras. Although this move seemed promising, the action-camera company was unsuccessful in manufacturing and marketing a drone that customers actually wanted. Earlier this year, GoPro decided to exit the drone business.Ultimately, you should never lose sight of what your customers expect from you, and never interrupt your mission to deliver that to them in a more effective way.Be willing to outsource.Your core competencies may be too important to stray from, but you have some wiggle room when it comes to anything outside of those functions. These are areas where you can afford to outsource work to other companies when that makes sense both financially, and from a quality perspective.With all the resources you put toward enhancing your core value proposition, you aren’t going to be able to do everything as well as some companies can do one thing. If your organization needs to outsource functions such as human resources or business development so you can focus on what you do best, then don’t hesitate.Always bring it back to the customer.The best way to ensure you aren’t getting distracted from your mission is to tie everything back to your relationship with the customer. If the choices you make are in service of improving your customers’ overall experience, then you’ll always find yourself on the right track.That doesn’t mean every decision will yield positive results, but it will help you narrow your decision-making so you don’t lose sight of the one relationship you absolutely can’t afford to ignore. Numerous studies have proven time and time again that the quality of the customer experience is, by far, the most important part of any business.Related: 5 Distractions That Are Productivity Poison (and How to Avoid Them)To succed, entrepreneurs must not get caught in the “shiny object” trap. Instead, they need to focus on optimizing their resources and delivering unparalleled value to their customers. 5 min read
Categories: Howell News,News 03May Rep. Howell hails House budget approval State Rep. Gary Howell voted on Tuesday for approval of the House version of the state budget, which includes record funding for K-12 education and funds the state at a level below that recommended by the governor.Howell, of North Branch, voted in favor of the budget for the new fiscal year, a conservative blueprint that invests in the state’s future.“I am pleased that we are providing K-12 schools the most money they have ever had, including additional funding for at-risk students,” Rep. Howell said. “We also are opening more opportunities for skilled trades training, which will help fill high-demand jobs in the state.“Additionally, our budget is restrained to the point that our proposal is below the amount recommended by Gov. Snyder,” Howell said. “We have trimmed inefficiencies and government waste to save taxpayer money.”Highlights of the budget include:Allocating the highest funding in state history for K-12 schools with a proposed $14.3 billion; improving access to skilled trades training through career and technical education.Making life better in communities across Michigan by adding money for road repairs, public safety departments, parks and other programs to improve our daily lives.Increasing funding for public safety by adding 100 more Michigan State Police troopers.Making health care more effective and efficient, with an enhanced focus on improving mental health care.Paying down retiree debt and adding to state government’s main savings account for tough times, pushing that emergency fund above $1 billion.The bills now go to the Senate for consideration.
In This Issue. * Safe Havens get unwound. * RBA disses the A$ again! * Spending more than we make, why not? * China’s Gold shipments up 51% this year so far. Saber Rattling Quiets Down.. Good Day! . And a Tom Terrific Tuesday to you! Well, Front and Center this morning, I feel like I’m becoming like the main media, and focusing on stupid stuff instead of the things that we should be focusing on, for this morning, I’m going to talk first about a couple of emails I received yesterday from people that were quite upset with me for calling the country of Ukraine, “the Ukraine”. I do understand the difference, but really, a simple explanation would have done the trick! So, I apologize to all Ukrainians who felt I was putting them back in the Russian stable.. Ok, dear readers, you get what I’m talking about here, right? I mean you don’t call Japan, “the Japan”, or France, “the France”. But funny thing, you do call our country The U.S.! As if we’re still a group of colonies! HA! Well, do you get the feeling that there’s little to talk about today, and Chuck is doing his best to beat around the bush this morning? If you do, you win a Gold Star! Speaking of Gold, yesterday, the shiny metal gained over $20 and pushed ahead of the psychological level of $1,350. But that was all “fear trading” as I talked to you yesterday morning about the saber rattling going on in the country of Ukraine. Overnight, all that saber rattling appeared to be exaggerated, and Gold has backed off the $1,350 level, by $12. Have you ever listened to the Moody Blues, Seventh Sojourn Album? For over 40 years it has always been one of my faves. New Horizons from that album is playing right now, and I had to turn it up, as this is a song that gives me peace of mind. How can I be my usual smart alec self after listening to this song? I’ll do my best! But you should really, dig that album out of your old albums bin, and put it on the turntable again.. Well, the Reserve Bank of Australia (RBA) kicked off this busy week of Central Bank meetings and Job Jamborees with a meeting of their own last night, and kick things off is what they did! The RBA decided to kick the Aussie dollar (A$) off the path to recovery last night, by emphatically mentioning that the “currency remains high by historical standards”. Once again, I used to like the RBA and thought of them as prudent, for they always seemed to have price stability as their main goal. By wishing, and hoping, and thinking and praying that the A$ will get weaker the RBA is inviting inflation into their economy, and that’s not providing price stability, folks. Shame on you RBA! Yesterday, it was all about the safe havens, and today it’s back to kicking sand in the face of Japanese yen, Gold, and francs. The U.S. Sec. of State, Kerry, is visiting Kiev today, so he must have put the fear of God into the Russians and had them back off, and end the saber rattling. Or maybe, as I said above, it was all exaggerated. Russian President, Putin has decided that there’s no need to send troops into Ukraine, and that has everyone breathing easier this morning. And with that we have the safe havens on the selling blocks today. The euro is attempting to get back on the rally tracks this morning, after getting sold yesterday. I doubt that the euro will get much traction though, as we head into the European Central Bank (ECB) meeting on Thursday. So, any traction it gets will be hard fought for! I still believe that we’ll see better things from the euro this year as I feel the single unit will be able to add on to last year’s positive gains. The euro is far from being out of the woods, given the peripheral countries of the Eurozone’s problems, but as long as relative calm can continue to be cast over the Eurozone, the euro will find ways to inch forward in price. The U.S. Data Cupboard was choking on the data it had to spit out yesterday. First and foremost, the U.S. PMI (manufacturing) index didn’t show that it had any problems with the “bad weather” in Feb, and gained. That’s a good sign for the U.S. economy and the first one we’ve seen in awhile. But then we had the Personal Income and Spending data. We simply cannot help ourselves when it comes to spending money, and in some cases spending money we don’t have! January consumer spending was up .4%, while January consumer income was up only .3%.. So once again, we spent more than we made. When you put the exploding Consumer Credit numbers up with these spending reports then the picture begins to become HD quality. Oh, and an ugly step-sister to all this is the larger than should be comfortable to Fed Heads, Margin Debt, just keeps growing. I don’t want to spoil the party so I’ll go. I would hate my disappointment to show. So, just go ahead and spend, and you’ll find out in the end, that it would have been better to save. On a sidebar, (I’ve seemed to go on a lot of these today, eh?) When the stock market last crashed (remember the tech bubble?) I had gone on record, months prior to the mess exploding, saying that IF the Fed, led by Big Al Greenspan, wanted to truly slow the stock market down, all he had to do was raise the initial Fed Call, margin rate, which stands at 50%… When I was a young man learning how a margin dept works at the brokerage firm Stifel Nicolaus, the initial Fed call margin rate was 65%… When it was dropped to 50%, stocks took off and never looked back, well that is, until the tech bubble popped. Just a bit of history for you. And getting back to spending more than we make. a report that EverBank posted on Google+, says that 1 in 3 Americans don’t save. And that only 68% of Americans spend less than they make and save the difference. That’s down from 73% at the start of the depression, when everyone was scared straight, and decided to shore up their own personal balance sheet. (remember that series “Scared straight”?) Well, that’s what happened, but now it’s back to spending, and not just one’s own money, but spending other people’s money! One day a huge appreciation and the next day a huge depreciation. That’s what’s gone on with the Chinese renminbi / yuan these last two days. It’s as if the People Bank of China (PBOC) is testing the waters of volatility. Just to see how it works, plays out, affects markets, etc. For there is no reason that they would allow a huge appreciation one day, and reverse it the next day, unless they were testing the waters of volatility. Well, today is Shrove Tuesday, or Fat Tuesday. I was in error last week when I talked about it being National Pancake day. National Pancake Day is today. So, drop by an IHOP and get your free stack of pancakes! I could use some pancakes, I think, today, as my stomach is rolling around and not behaving. Saturday was Mardi Gras. Here in St. Louis, I think we have the 2nd largest Mardi Gras celebration, so it’s a big deal here. For What It’s Worth. I’ve told you all about this fellow named Koos Jansen, who does tons of work researching Gold shipments, etc. in China.. He normally posts his thoughts on a website called ingoldwetrust.ch and the GATA people post it too. Koos then goes to Google+ and makes a post. This morning, Ed Steer posted it too, so it’s all over the place, but not in places that you dear Pfennig reader would normally see, so I have if for you here! Here’s Koos Jansen.. “The Shanghai Gold Exchange (SGE) is back on schedule publishing their trade reports on Friday that cover the previous trading week. Last Friday’s report covered the trading week February 17 – 21. For me the most important numbers is always the amount of physical gold withdrawn from the vaults as this equals Chinese wholesale demand. Withdrawals in week 8 (February 17 – 21) accounted for 49 tonnes, year to date there have been 369 tonnes withdrawn from the vaults. If we divide the later by the number of days of the corresponding period (52) we come up with an average demand of 7.09 tonnes per day – this includes weekends and the one week holiday at Lunar year when the SGE was closed. I got a few request regarding demand compared to last year and daily moving averages. Great ideas which I have carried out (request are always welcome, we’re doing this together). Compared to last year demand is up 51 % over the same period. Of course we had the shocker in April 2013 when withdrawals exploded to 117 tonnes in week 17. I don’t expect any spikes that big this year so probably this year’s growth compared to 2013 in percentages will be decreasing when we’ll pass April. Nevertheless, the daily average of 2013 was (2197/365) 6.02 tonnes, while this year we’re up to 7.09 tonnes. China is on schedule to establish a new record, if the world can supply any more gold. The longer this insatiable demand continues, the more I start to ask myself where this gold is coming from. We know form Swiss refineries they’re having a very hard time to source this much gold for China.” – Koos Jansen Chuck again. Great stuff! The Chinese like to be secretive about their shipments, production and overall usage of Gold, but more and more these numbers are coming to the front page, and none of them indicate to me that China has given up their goal of having more Gold than any other county on earth, to: 1. Make the rules when the countries sit down and show their Gold, and 2. To back the renminbi with Gold to make it the most attractive currency on the block! To recap. It’s Shrove Tuesday, or Fat Tuesday for everyone else that isn’t Irish! The saber rattling in Ukraine has quieted down, and Putin said there’s no reason to send troops into Ukraine. So, with the quieting down, the safe havens which were what it was all about yesterday, are getting sold this morning. The euro is back on the rally tracks, and the RBA dissed the A$ last night, saying that it was “still high”. And Chuck learns a lesson on talking about countries.. Currencies today 3/4/14. American Style: A$ .8960, kiwi .8405, C$ .9040, euro 1.3765, sterling 1.6695, Swiss $1.1305, . European Style: rand 10.8075, krone 6.0015, SEK 6.4370, forint 225.60, zloty 3.0410, koruna 19.8690, RUB 36.10, yen 101.90, sing 1.2690, HKD 7.7610, INR 61.85, China 6.1236, pesos 13.27, BRL 2.3435, Dollar Index 79.99, Oil $103.82, 10-year 2.64%, Silver $21.19, Platinum $1,445.00, Palladium $747.00, and Gold. $1,333.08 That’s it for today. I believe that we will have some cooks (people in the office) making their best Fat Tuesday creations for today. I sure hope my stomach settles down so I can partake! Well, after today, you’ll only have me 5 more days before I head to Spring Training! After walking across the wind tunnel bridge this morning, I have to say that I can’t wait! I have to go where it’s warm, and that’s not here! The Sun continues to move north. Mike and Chuck keep track of it as it rises in the East. We had a fund raiser at a pizza joint last night for the Lindbergh High School Water Polo Team. All the kids, and grandkids were there, so dad got to buy dinner for everyone! My two grandsons, Everett and Braden were entertaining, and at one point they both decided they needed to go to the bathroom. I thought, that’s not going to turn out good. HA! Funny kids! I hope they generated enough money for the program. Oldest son, Andrew is the head coach of the water polo team, so even after Alex graduates this spring, we’ll still be going to games. And with that, Mike is here, that means this is late! Not as late as yesterday, as I had to retype the whole letter, long story. So, I hope you can make this a Tom Terrific, Shrove and Fat Tuesday! Chuck Butler President EverBank World Markets
Most investors outside North America not only saw their currency lose value but also lost money in their stock market. His fellow Russians were hit especially hard. Whoever owned gold, though, had avoided these debilitating losses and was actually sitting on a profit. The article concluded by congratulating those with the foresight to buy gold, which unfortunately didn’t include many of his fellow citizens—but it did include him. Dmitry has every right to feel pleased with himself. While inflation raged all around him, the currency fell through the floor, and global crises remained escalated, his investment in gold had done exactly what it was supposed to do: protect him against currency and monetary calamity. In fact, he’d gained more with gold than he lost in ruble purchasing power. He’d read warnings that this could happen—warnings others had dismissed as the ravings of loony gold bugs. He had been skeptical, frankly, and it hadn’t happened exactly as he thought it would, but now he sure was glad he’d decided to play it safe and bought some gold as insurance. He wondered what those in North America thought about this phenomenon… Did they see the writing on the global economic wall—or did they imagine they were immune because their stock market had risen so much while gold remained weak in their currency? Did they really believe their central bankers were wizards endowed with supernatural powers that others lacked? Didn’t they remember Ben Bernanke insisting in 2007 and 2008 that there was no crisis and that everything was under control? It seemed to Dmitry that many of them were kidding themselves, because he knew that at some point, the very thing that happened to inflation rates and currency values in his country could happen to theirs. And how gold would respond—as he now knew firsthand. Like him, sensible Americans who bought gold while it was on sale wouldn’t know the timing but would be prepared for the inevitable outcome of the currency-destroying policies their central bank had adopted, just like all the others. He hoped they saw it coming and envied their chance to take advantage of relatively low prices. Dmitry could hardly wait for tomorrow, the day the January BIG GOLD would be released. And it wouldn’t be just any issue, but a 50-page blockbuster edition that interviewed 17 experts on precious metals and included two actionable steps to kick-start 2015: a discount on international bullion storage; and a new recommended stock—one that Jeff Clark described as a must-own company that came with both safety and high potential. He hopes his friends check it out. Dmitry sipped his coffee drink at his favorite café in Moscow, flipping through the newspaper in front of him. It was full of bad news: currency troubles, ongoing sanctions from the West, rising inflation, and more. But he ignored all that. He turned to the investment section and began to scan the page, looking for the latest price of one specific investment. He went past the headline that screamed Russia’s inflation rate was up to 11.4% last year, as well as the article detailing the ruble’s debilitating 46.5% fall. He knew all those things and had experienced them firsthand. He went directly to the page that quoted the price of gold in rubles. And there it was. And this time, it wasn’t just a short price quote, but a full article on the topic of gold, starting with a headline that warmed his heart. “Gold Price in Rubles Rises 73% in 2014” The article detailed how gold had soared last year due to the depreciation of the ruble. What especially pleased him was that gold rose more than the ruble fell. It also outpaced the rise in inflation. The article included a chart of the last six weeks’ price movement, during which the ruble had taken an especially ugly drop. Dmitry wasn’t surprised to read that it wasn’t just the gold price in rubles that was up last year… The price of gold rose against ALL currencies in 2014—except the US dollar. Yes, gold was up in the euro, Japanese yen, Swiss franc, Canadian dollar, British pound, Australian dollar, New Zealand dollar, Chinese renminbi, Indian rupee, Swedish krona, Brazilian real, Israeli shekel, and South Korean won. Even more interesting was that gold outperformed most stock markets around the world…
For more than 60 years, it has been the standard of care to try to speed up childbirth with drugs, or to perform a cesarean section if labor was seen as progressing too slowly.Now a new set of recommendations is changing the game.In February, the World Health Organization released a set of 56 recommendations in a report called Intrapartum Care for a Positive Childbirth Experience. One key recommendation is to allow a slow labor to continue without trying to hurry the birth along with drugs or other medical interventions. The paper cites studies showing that a long, slow labor — when the mother and baby are doing well — is not necessarily dangerous.A little history is required to understand the importance of that one recommendation, says Dr. Aaron Caughey, chair of the Department of Obstetrics and Gynecology at Oregon Health & Science University, who did not work on the report. In 1955, Dr. Emanuel Friedman studied 500 women and concluded that labor is normal when, during the intense phase of contractions, the cervix opens at a rate of at least one centimeter (about 0.4 inches) an hour. “Dr. Friedman showed that 95 percent of women progressed” at this rate, says Caughey. “And that became the standard of care.”Called Friedman’s Curve, the standard persisted until 2010 when a large-scale study of more than 100,000 women by Dr. Jun Zhang, a researcher at the National Institutes of Health, concluded that healthy mothers at low risk for birth complications and their babies did just fine even when labor progressed more slowly than one centimeter per hour. In 2014, the American College of Obstetrics and Gynecology put out a consensus paper co-authored by Caughey overturning Friedman’s Curve, which had been followed by most doctors since the 1950s.But change in practice comes slowly, says Caughey, and many physicians around the world still consider a long, slow labor reason enough to speed it along with a drug like oxytocin or to wheel the mother into an operating room for a C-section.The big take-home message from the report is that a slow labor can be a safe labor. But just as important are the other recommendations that emphasize the kind of care women should be entitled to throughout labor and delivery. Worldwide, 140 million babies are born every year, most of them without complications to mothers or babies. But the recommendations emphasize that too many women suffer during childbirth or don’t have the kind of birth experience they want.The new WHO recommendations include allowing a woman to be accompanied by a companion of her choice during childbirth, honoring her decisions about pain management and delivery position, and providing her with confidentiality and privacy. These guidelines are important all over the world but are particularly relevant in poor countries where resources are scarce and women in labor are often crammed into overcrowded wards.For a closer look at the overall guidelines, we spoke with Dr. Olufemi Oladapo, medical officer in the maternal and perinatal health team at WHO and an author of the recommendations. This interview has been edited for length and clarity.The new recommendations say that a long, slow labor is not a good reason in itself to give drugs to speed labor, perform a C-section or otherwise medically step in. Can you talk about that specific recommendation?This is a game-changing kind of recommendation. It goes against an ages-long benchmark categorizing how quickly labor should progress. Previous thinking was that less than one centimeter per hour was abnormally slow. But we now know that this benchmark is unrealistically fast for some women, and interventions to correct the rate of dilation can do more harm than good. If a woman is dilating slower than one centimeter per hour, as long as she’s making some progress, she can still have a vaginal delivery. Using that old, fixed rule for every woman doesn’t make sense. Just like in many things, humans tend to differ.What do women themselves want in the childbirth experience?Women want to be involved in making decisions. They want a sensitive, caring, well-motivated staff taking care of them. They want to be in control of the process. And, of course, they want a healthy baby and to be healthy themselves. That’s what women are saying they want.The guidelines emphasize respect and dignity. What are some instances of “disrespectful and undignified care” referred to in the report?My department published a review of disrespect of women globally during childbirth. It’s worse in some places than others, but it’s everywhere. It has to do with physical abuse, like slapping the woman on the thigh during delivery. Or yelling and shouting at her to push the baby out. There is negligence, for example, if the woman is left alone for long periods during labor.Are cultural differences taken into account in these recommendations?Yes. An example is the recommendation having to do with birth position. A woman should be allowed to choose the position she wants, maybe squatting or sitting. That might be the position of her culture.Many of these recommendations are aimed at encouraging a normal, vaginal delivery for healthy women not at risk for medical complications. What if some women request cesarean section even though it’s not medically necessary? We make clear that if someone wants an intervention, it’s the responsibility of the provider to explain the pros and cons of an unnecessary medical intervention. In some cultures, the medical intervention is considered the better quality of care.In China, during the one-child policy, many women had cesarean section, maybe because they knew they would only have one child. [An initial C-section usually means other births will also be C-section, which can be even riskier. If mothers know they will only have one baby, they don’t worry about C-section risks.]Now that the policy has changed, I understand that’s changing. But an invasive intervention means the woman is taking an extra risk. You have to explain to the woman that even in a high-income setting, the risk of a cesarean is not zero.How will you spread the word on these recommendations?There has been a lot of social media. We’ll hold regional conferences: Africa in April, Southeast Asia in June. Others will follow. Each region can run individual workshops.What do you hope comes from these guidelines?We hope that every woman receives care that maintains her dignity from the time she walks into a facility until she is discharged.Susan Brink is a freelance writer who covers health and medicine. She is the author of The Fourth Trimester, and co-author of A Change of Heart. Copyright 2018 NPR. To see more, visit http://www.npr.org/.
As a science columnist for The New York Times, Carl Zimmer had reported extensively about genetics and the role gene mutations play in various ailments. After a while, he got to wondering about what secrets his own genetic code holds.”I wanted to know if there was anything I needed to worry about,” Zimmer says. “We all think back to our relatives who got sick and then wonder, ‘Is that in me?’ “So Zimmer worked with a genetics counselor to get his entire genome sequenced — an experience he describes as “very nerve-wracking.” He worried that he would discover a mutation that would put him on the path for a particular disease.As it turned out, the counselor told Zimmer he has a “boring genome.” Though Zimmer initially hoped for a more “exciting and exotic” assessment, the counselor reminded him “A boring genome is a really good genome.”Zimmer writes about the broader implications of genetic research and testing in his new book, She Has Her Mother’s Laugh: The Powers, Perversions and Potential of Heredity.Interview HighlightsOn how the new genetic editing technology known as CRISPR worksWhat happens with CRISPR is that scientists will design a molecule — think of it as a probe — and it will search around in the DNA in a cell until if finds a very specific short sequence. And it will grab onto it, and it brings on with it basically molecular scissors, which will then cut the DNA at that spot — kind of like cutting tape. And you can cut out a segment of DNA. And if you just do that, DNA will heal itself. Basically the two loose ends will stitch themselves together, and now that piece is just missing. Or you can add in a little piece of different DNA, and you can actually get the cell to put in that new piece of DNA where you just cut out the old one.On whether CRISPR technology could be used to treat diseases in humansWe’re just on the verge of human trials. They will be starting, hopefully very soon, for diseases like sickle-cell anemia. There’s actually a lot of research on muscular dystrophy as well. There are a few key diseases where scientists think these would be the best places to start. To basically inject CRISPR molecules into people’s bodies; these CRISPR molecules would then go to certain kinds of cells and repair one particular spot in their DNA. And that treats the disease.We shouldn’t look at this as a panacea. … There have been earlier kinds of treatments known as gene therapy, where you basically try to add an extra gene into someone’s cells. And that [seemed] like it was just a slam dunk, but then it turned out to not work very well for years and years. … So CRISPR could be even more exciting and truly revolutionary. We just have to wait and see what this first generation of human clinical trials show us.On his visit to an insectarium where a scientist is breeding genetically modified mosquitoes that are resistant to malariaFirst of all, you have to gown up before you go in there. … And then you go through an air lock, and then you’re in this room where there are mosquitoes living in all their different life cycles.So there’s a dark room where the female mosquitoes are laying their eggs, because they like to do it in the dark. And then the scientists pull the eggs out from these rooms and they inject DNA into them and then they put them in water, because that’s where mosquito larvae like to develop.And so you go into this other room where there are these tubs of water, and these snake-like things are slithering around in there and then they develop into adults. And the females need to drink blood; so [researchers] found that the containers for movie popcorn work really well. What they do is, they basically clamp a warm container of calves’ blood on top of them, and then the mosquitoes are underneath — on the underside of the plastic lid — basically poking through and drinking the blood and fattening themselves up. …You can tell that they’ve been genetically altered because they have red eyes, which is kind of spooky. But you look at that and you say, well, that means that these could be the cure for malaria. It really could happen. And hundreds of thousands of people die every year of malaria. We’ve thrown everything we can at it and this parasite is still knocking us down worldwide. So, maybe this could be it – so, that’s actually quite exciting.On how genetic testing was used in the Golden State Killer caseFor the Golden State Killer case, what somebody decided to do was take the DNA that they had from these crime scenes, and upload it to one of these open-access sites — not a commercial site — and then see if they could find any close matches. And they found that there were some people that looked like they were distant cousins of this person. And they went and did the genealogical research to figure out “Well, how would they be related?” And then said “OK, who are the possible relatives that this person could be, and where do they live?” And that actually helped narrow down their search until they made an arrest.On whether genetic testing companies will protect user privacyYou can choose different levels of privacy with a lot of these services. So, for example, some people will say “I want you to look at my DNA. I want you to tell me about my ancestry.” … For 23 and Me they’ll give you a few bits of information about your medical conditions, and that’s it. But they will try to get you to opt in to sharing your data for their own basic research. At 23 and Me, for example, there’s a whole team of researchers who are studying all sorts of … diseases, sleep patterns and so on. And then they will also go into partnerships with drug development companies who will take their data, looking at, say, 50,000 people with lupus and 50,000 people who don’t have lupus, and try to look for the genetic differences. Those could point the way toward possible drugs.Phyllis Myers and Seth Kelley produced and edited the audio of this interview. Bridget Bentz and Seth Kelley adapted it for the Web. Copyright 2018 Fresh Air. To see more, visit Fresh Air.
Americans could be forgiven for not knowing that much about measles. After all, it’s been 51 years since an effective vaccine was introduced, quickly turning the disease from a common childhood experience to a rarity, and nearly two decades since the disease was declared eliminated from the U.S. But outbreaks have surfaced throughout the country over the past few months, affecting more than 700 people.Most of the cases are linked to people who have traveled abroad — to countries where measles is more common — or spread within insular and close-knit communities, like New York’s Orthodox Jewish community. But now public health officials are concerned that we have reached a risky point where measles could regain a foothold in this country. This could still be prevented if vaccination rates in these communities go up.Here’s what you need to know about measles, its spread, and who is at risk.How contagious is measles? Measles, caused by the rubeola virus, is one of the most contagious infectious diseases. If an infected person coughed in a room, 90% of nonvaccinated people in that room would become infected. The virus can linger in the air for up to two hours, according to the Centers for Disease Contol and Prevention.Someone infected with the virus can begin spreading the disease four days before showing any outward signs of infection, making it harder for public health officials to contain outbreaks.How common are serious complications? Symptoms of measles include high fever, cough, runny nose, white spots inside the mouth, and rashes that spread across the skin.While most recover from the infection, measles can lead to serious complications. About 1 in 4 individuals who contract measles will be hospitalized. One in 10 children with measles will develop ear infections, which can lead to permanent hearing loss. One in 1,000 will develop swelling of the brain (encephalitis), which can result in permanent brain damage. A similar proportion will die from the infection.Who is most at risk of contracting and having serious complications of measles? Unvaccinated young children have the highest risk of contracting measles and developing serious complications from the disease. The CDC typically advises that the first dose of the vaccine be administered at 12 months, making young infants especially susceptible. However in light of the current outbreak, CDC officials recommend the vaccine for infants between 6-11 months who are traveling to countries with measles outbreaks.What is herd immunity, and are we at risk of losing it? Herd immunity is a term that describes how many people in a population need to be immune for the population as a whole to be protected. Herd immunity protects those in a population who, for whatever reason, can’t be safely vaccinated. The proportion of a population that needs to be immune for herd immunity depends on the disease and how it is transmitted.Epidemiologists explain it like this: 100% – (1/the basic reproductive number of the disease)% = Herd immunity thresholdThe basic reproductive number of a disease is the average number of people one person can infect in a totally susceptible population. Less contagious diseases require a smaller percentage of a population to be immune to prevent spread of a disease. But measles’ reproductive number is high, between 12 and 18, meaning that one person, on average, infects 12 to 18 other people. How this works out is that 93% to 95% of the population must be immune to prevent a single case of measles from spreading. Above that threshold, the virus just keeps hitting walls of immunity, and can’t spread. But below that threshold, the virus can gain a foothold and spread among vulnerable members of a population.It’s been said that measles was “eliminated” in 2000 from the U.S., but now we’re seeing a new outbreak. What’s the difference between eliminating and eradicating a disease? According to the CDC, a disease is eliminated from a geographic region when no more endemic cases of the disease occur within that region. Outbreaks can still happen but are triggered by travel to countries where the disease is not eliminated.A disease is eradicated when the worldwide incidence of infection drops to zero. Smallpox is an example of a disease that has been successfully eradicated.Measles is still present in many countries around the globe, so eradication is still a way off.Where are the biggest outbreaks, domestically and globally?The largest U.S. outbreaks are occurring in Rockland County and Brooklyn, N.Y. Washington state had over 70 cases in early 2019, though authorities recently declared the outbreak over in the Pacific Northwest, as there have been no new infections in over six weeks.Most of these outbreaks have occurred in small, insular communities with low vaccination rates, often owing to high levels of vaccine hesitancy. Globally, recent outbreaks dwarf U.S. numbers. The biggest outbreak in the past six months has been in Madagascar, with just under 70,000 cases; and in the past 12 months, Ukraine, India and Brazil have seen large outbreaks, among other countries.Does the vaccine’s effectiveness wane? Should adults get revaccinated?According to the CDC, people who received two doses of the MMR vaccine are considered immune for life and do not need to be revaccinated. However, adults born between 1957 and 1967 should be revaccinated, as early vaccines were less effective than the vaccine available after 1967. Adults born before 1957 are assumed to have contracted the disease as a child and thus have natural immunity.Women who are considering getting pregnant should also check on their vaccination status, according to the CDC. Copyright 2019 NPR. To see more, visit https://www.npr.org.
On rare occasions as a kid, Renzin Yuthok and his family got to share a special breakfast. They’d gather around a table in their home in Bellevue, Wash., his dad would roll tsampa flour, butter and tea into balls called pa, and then he’d hand them out to his kids.The meal served a symbolic purpose for Yuthok: “From a very young age, [Tibetans] are taught that … reclaiming our homeland … is what our highest aspiration could be,” he says. Yuthok’s family fled Tibet in the 1950s, but their breakfast — and its grounding ingredient, tsampa — kept him connected to that dream.The word tsampa in Tibetan usually refers to ground-up, roasted barley flour, although occasionally the flour comes from wheat or another grain. It can be made into cereal, mashed into a poultice or mixed with yak butter and tea to make calorie-dense energy balls for long mountain treks (or breakfast treats for schoolkids). It’s tossed into the air at religious ceremonies and can be incorporated into wedding cakes. The Dalai Lama says he eats it for breakfast.Thanks to its hardiness (it’s one of the few cereal crops that can survive on the high, arid and harsh Tibetan Plateau), barley has sustained the Tibetan population for thousands of years. Scientists say the cultivation of barley may have enabled ancient Tibetans to expand their civilization into the Himalayas. Researchers have found barley traces in 2,100-year-old remains of tea, which means it’s possible that tsampa was eaten during that time.But over the last century, tsampa has become even more than a culturally significant staple food. It’s become a centerpiece of Tibetan identity and a tool of protest.Calling all tsampa eatersBetween 1950 and 1951, China annexed the region of Tibet. Most Tibetans called the event an invasion, while the Chinese, in documents solidifying the annexation, called it a peaceful liberation (though it involved a bloody battle in the region of Chamdo).Though Tibet’s rulers rejected Chinese claims to their territory, Tibetans had few sources of political unity back then. “Tibetans are diverse in language, custom, habits — there’s a lot of diversity within the single Tibetan group,” says Tsering Shakya, a Tibetan historian and associate professor at the University of British Columbia. So when the Chinese army entered the region in 1950, Tibetans initially lacked a unifying force.Tsampa — which is eaten across Tibet — soon became that force. “When [Tibetan resistance leaders] were looking to unite [Tibetans] into a single identity, they adopted tsampa as a symbol,” Shakya says. In 1952, two years after the Chinese occupation began, The Tibet Mirror, an independent Tibetan language newspaper, published a letter calling for revolt. Its first call-out? Tsampa eaters:”We, the tsampa eaters, chuba [traditional Tibetan outerwear] wearers, dice players, raw and dried meat eaters, followers of Buddhism, Tibetan language speakers…we must make the effort to end the [Chinese] occupation.”Years later, in 1956, the Mirror again called out to “tsampa-eaters” to “unite your minds” and “stand up!” The Mirror’s exhortations were one of a series of events that led to what’s known today as the 1959 Tibetan Uprising, when thousands of Tibetan protesters gathered in the streets of the capital city, Lhasa, calling for Tibet’s independence from China and later, mobilizing to fight the regime. The Dalai Lama fled the region during this time. In an essay about this time period, Shakya writes, “If Buddhism provided the atom of Tibetanness, then tsampa provided the sub-particles of Tibetanness. The use of tsampa transcended dialect, sect, gender, and regionalism.”This growing unity, coupled with support from anti-Communist countries like the U.S., was not enough for the relatively small Tibetan population to defeat the powerful Chinese army. They lost their fight for independence and are governed as part of China to this day. Thousands of Tibetans were killed during the 1959 uprising, and the Tibetan government-in-exile has estimated that the occupation led to the loss of 1.2 million lives.Making a comebackSince the 1950s, China’s incorporation of Tibet has fragmented tsampa’s place as the region’s staple grain, Yuthok says, partly because of an influx of Han Chinese who tend to prefer crops like wheat and rice.Still, people in Tibet eat far more barley per person than nearly anywhere in the world. And tsampa’s importance to Tibetan identity and struggle has not diminished. If anything, it has been making a comeback.Starting in 2008, a new wave of revolts began. In 2009, protesting monks cried, “Rise up, all tsampa-eating Tibetans!” In 2012, protesters ate tsampa and threw it up into the air during a mass prayer; at a different rally, according to a witness, monks were “chanting mantras and eating tsampa in protest.”So important was tsampa to these protests that the modern-day Tibetan resistance movement often goes by another name online: The Tsampa Revolution, or #TsampaRevolution.Tsampa has also found its way into Tibetan political music and youth culture. In 2012 the rapper Shapaley, who spent his childhood in Tibet, released a song called “Tsampa” on YouTube. The accompanying music video features the rapper sitting behind a bowl of tsampa, a traditional bag for storing the grain and a steaming cup of butter tea.”Our parents gave us tsampa so we’ll give it to our kids / the Tibetan spirit will always remain,” Shapaley raps. “You can threaten us but we keep doing our thing … you can’t stop us!” At the end of the video he throws what looks like a cloud of tsampa into the air, in homage to the traditional sang-sol ceremony — or perhaps to the monks protesting in Tibet that same year, thousands of miles away.A health food trend?Yuthok, who was born in Taiwan and moved to the U.S. as a kid in the 1970s, is now working with his aunts Namlha and Tzesom as they try to spark another movement with tsampa in North America. Their company, Peak Sherpa, sells tsampa as a hot cereal and as “energy bites” — sort of a cross between an energy bar and the traditional pa. The cereal, I can attest, is delicious — the grains are smaller and denser than oatmeal, making for a pleasing nutty taste without the gluey texture of oats.Because the barley used in tsampa doesn’t have to be heavily processed, it retains more nutrients, and the flour’s healthfulness rivals that of other ancient grains. Tsampa is high in fiber and essential minerals and it’s prebiotic, meaning it helps promote the growth of healthy gut bacteria. It has a low glycemic index, which helps keep blood sugar from spiking. Plus, from a marketing perspective, it could be seen as one more in a line of Tibetan foods that have caught on with the health-food crowd — like goji berries and butter tea (reinvented as bulletproof coffee here in the U.S.).So why has the Yuthoks’ company had a tough time breaking into the U.S. market? While they’re still relatively new, “it’s been really hard,” he admits. “I’d say we’re definitely a niche product at this point.” Though, he notes, “we definitely have our fans.”Here’s what he suspects: Hot breakfast cereals are a highly competitive sector. Oats are nutritionally comparable to barley. And at only a few cents per serving, oats are much cheaper — and they’re nostalgia-inducing.”People have a relationship with the Quaker guy, you know?” he says. “They love that guy, and what’s not to love?”Additionally, American barley is not exactly easy to eat. Most barley grown here comes in a tough, inedible hull that’s difficult to remove, making it hard for food producers to create “whole grain” foods out of the original plant, unlike rice or wheat. Much of our barley is used to brew beer and other alcoholic beverages.But that could very well shift soon. Tibetan barley lacks a tough outer hull, meaning it’s easy to thresh, like wheat — and that’s likely because of selective breeding by Tibetans over thousands of years, says Patrick Hayes, a professor of barley breeding and genetics at Oregon State University. Hayes is working on popularizing these Tibetan barley strains in the U.S. He plans to use them to develop locally adapted varieties.So far, so good. But Hayes is careful to acknowledge the true source of his current success. “We wouldn’t have been able to do this work without what [Tibetans] did over thousands of years.” If he ends up converting us all to barley, we will have tsampa eaters to thank.Susie Neilson is an intern on NPR’s Science Desk. Follow her on Twitter: @susieneilson. Copyright 2019 NPR. To see more, visit https://www.npr.org.
Reviewed by James Ives, M.Psych. (Editor)Oct 15 2018Only a small proportion of cases of dementia are thought to be inherited – the cause of the vast majority is unknown. Now, in a study published today in the journal Nature Communications, a team of scientists led by researchers at the University of Cambridge believe they may have found an explanation: spontaneous errors in our DNA that arise as cells divide and reproduce.The findings suggest that for many people with neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, the roots of their condition will trace back to their time as an embryo developing in the womb.In common neurodegenerative diseases, toxic proteins build up in the brain, destroying brain cells and damaging brain regions, leading to symptoms including personality changes, memory loss and loss of control. Only around one in twenty patients has a family history, where genetic variants inherited from one or both parents contributes to disease risk. The cause of the majority of cases – which are thought to affect as many as one in ten people in the developed world – has remained a mystery.A team of researchers led by Professor Patrick Chinnery from the Medical Research Council (MRC) Mitochondrial Biology Unit and the Department of Clinical Neurosciences at the University of Cambridge hypothesised that clusters of brain cells containing spontaneous genetic errors could lead to the production of misfolded proteins with the potential to spread throughout the brain, eventually leading to neurodegenerative disease.”As the global population ages, we’re seeing increasing numbers of people affected by diseases such as Alzheimer’s, yet we still don’t understand enough about the majority of these cases,” says Professor Chinnery. “Why do some people get these diseases while others don’t? We know genetics plays a part, but why do people with no family history develop the disease?”To test their hypothesis, the researchers examined 173 tissue samples from the Newcastle Brain Tissue Resource, part of the MRC’s UK Brain Banks Network. The samples came from 54 individual brains: 14 healthy individuals, 20 patients with Alzheimer’s and 20 patients with Lewy body dementia, a common type of dementia estimated to affect more than 100,000 people in the UK.Related StoriesNew app created to help people reduce exposure to anticholinergic medicationsCommon medications can masquerade as dementia in seniorsSlug serves as ‘command central’ for determining breast stem cell healthThe team used a new technique that allowed them to sequence 102 genes in the brain cells over 5,000 times. These included genes known to cause or predispose to common neurodegenerative diseases. They found ‘somatic mutations’ (spontaneous, rather than inherited, errors in DNA) in 27 out of the 54 brains, including both healthy and diseased brains.Together, these findings suggest that the mutations would have arisen during the developmental phase – when the brain is still growing and changing – and the embryo is growing in the womb.Combining their results with mathematical modelling, their findings suggest that ‘islands’ of brain cells containing these potentially important mutations are likely to be common in the general population.”These spelling errors arise in our DNA as cells divide, and could explain why so many people develop diseases such as dementia when the individual has no family history,” says Professor Chinnery. “These mutations likely form when our brain develops before birth – in other words, they are sat there waiting to cause problems when we are older.””Our discovery may also explain why no two cases of Alzheimer’s or Parkinson’s are the same. Errors in the DNA in different patterns of brain cells may manifest as subtly different symptoms.”Professor Chinnery says that further research is needed to confirm whether the mutations are more common in patients with dementia. While it is too early to say whether this research will aid diagnosis or treatment this endorses the approach of pharmaceutical companies who are trying to develop new treatments for rare genetic forms of neurodegenerative diseases.”The question is: how relevant are these treatments going to be for the ‘common-or-garden’ variety without a family history? Our data suggests the same genetic mechanisms could be responsible in non-inherited forms of these diseases, so these patients may benefit from the treatments being developed for the rare genetic forms.” Source:https://www.cam.ac.uk/research/news/many-cases-of-dementia-may-arise-from-non-inherited-dna-spelling-mistakes
This week, “What the Health?” panelists discuss, among other things, how the House Democrats’ leadership battle could affect the congressional health policy agenda.The panelists are Mary Agnes Carey of Kaiser Health News, Margot Sanger-Katz of The New York Times, Alice Ollstein of Politico and Anna Edney of Bloomberg News.As the post-election dust settles on Capitol Hill, the Democrats — soon to be in control of the House of Representatives — have begun the process of choosing their leadership team. How this shakes out will have a lot to do with how health policy agenda takes shape in the lower chamber.House Democrats nominated Rep. Nancy Pelosi (D-Calif.) to retake the speaker’s gavel, but she still needs to win over more of her colleagues to secure the speaker post in January.But all the action this week wasn’t focused on Congress. Food and Drug Administration Commissioner Scott Gottlieb unveiled a proposed overhaul of the FDA’s decades-old medical device approval process, and the Trump administration announced proposals it said would reduce Medicare prescription drug costs. Critics fear those changes could mean that some people with chronic diseases like AIDS or cancer might not have access to the drugs they need.Among the takeaways from this week’s podcast: House Democrats nominated Rep. Nancy Pelosi (D-Calif.) to retake the speaker’s gavel this week along with the rest of its leadership slate, Reps. Steny Hoyer of Maryland and Jim Clyburn of South Carolina. This is only the first step, though. The leadership positions will not be filled officially until January, when they are voted on by the full House. Although Pelosi is still wrangling for the support needed to earn her the required 218 votes, most insiders expect the Democrat’s leadership team to look much as it did the last time Democrats ruled the House chamber in 2010, when the Affordable Care Act became law. That means the House will likely be laser-focused on the necessary steps to protect the ACA. There may also be hearings on single-payer health insurance — a concept that is increasingly gaining interest and support within the caucus, and especially among some of its newest members. In the background, the Texas lawsuit that could overturn the ACA’s protections for people with preexisting conditions is still pending. That decision could come any day. Keep in mind, though, that whatever the court rules, it is likely to be appealed immediately and move up the legal ladder. And, in the interim, House Democrats may still move forward with legislation to strengthen those ACA safeguards. Such a measure could get some GOP support because many Republicans seeking re-election this year said they wanted to ensure that patients with preexisting medical conditions would not lose coverage. The FDA unveiled a proposed overhaul of its decades-old medical device approval system. Among its provisions, the plan includes steps to ensure that new medical devices reflect current safety and effectiveness features. Critics of the current system say it has failed to detect problems with some implants — like hip replacements that failed prematurely or surgical mesh that has been linked to pain and bleeding. The changes, if approved, could take years to implement and some might require congressional approval. The Trump administration proposed a series of changes to reduce the number of prescription drugs that all Medicare drug plans must cover. The proposal focuses on drugs in six “protected classes” and involves medications such as antidepressants, antipsychotic medicines, cancer drugs and antiretrovirals to treat HIV/AIDS. Administration officials have said the proposal could cut costs for Medicare, but patient advocacy groups say it could reduce patients’ access for much-needed treatments. The proposed changes would not occur until 2020, and Congress could intervene to stop them. This article was reprinted from khn.org with permission from the Henry J. Kaiser Family Foundation. Kaiser Health News, an editorially independent news service, is a program of the Kaiser Family Foundation, a nonpartisan health care policy research organization unaffiliated with Kaiser Permanente. Related StoriesCancer incidence among children and young adults with congenital heart diseasePopular herbal tea causes high-blood pressure emergency in patientMany thyroid cancer patients have no choice about radioactive iodine, study revealsAlso this week, Julie Rovner interviews KHN senior correspondent Jay Hancock, who investigated and wrote the latest “Bill of the Month” feature for Kaiser Health News and NPR. It’s about a single mother from Ohio who received a wrongful bill for her multiple sclerosis treatment. You can read the story here.If you have a medical bill you would like NPR and KHN to investigate, you can submit it here.Plus, for extra credit, the panelists recommend their favorite health policy stories of the week they think you should read too:Mary Agnes Carey: The New York Times’ “This City’s Overdose Deaths Have Plunged. Can Others Learn From It?” by Abby GoodnoughMargot Sanger-Katz: NPR’s “Rethinking Bed Rest for Pregnancy,” by Alison KodjakAnna Edney: The Washington Post’s “Overdoses, Bedsores, Broken Bones: What Happened When a Private-Equity Firm Sought to Care for Society’s Most Vulnerable,” by Peter Whoriskey and Dan KeatingAlice Ollstein: Wired.com’s “The Science Is Clear: Dirty Farm Water Is Making Us Sick,” by Elizabeth Shogren and Susie NeilsonTo hear all our podcasts, click here.And subscribe to What the Health? on iTunes, Stitcher or Google Play. Reviewed by Kate Anderton, B.Sc. (Editor)Nov 29 2018
Next Shivpal Yadav-led Pragatisheel Samajwadi Party leader found dead in AmethiThirty-three-year-old Rohit Agrahari was the state unit secretary and in-charge of party affairs in Ayodhya. The police officer said it appeared that his body was dumped after being killed.advertisement Press Trust of India Amethi(Uttar Pradesh)July 12, 2019UPDATED: July 12, 2019 14:06 IST The body has been sent for post-mortem. (Representational Image)A leader of the Shivpal Singh Yadav-led Pragatisheel Samajwadi Party (PSP) was found dead near the Amethi railway station on Friday, police said.Thirty-three-year-old Rohit Agrahari was the state unit secretary and in-charge of party affairs in Ayodhya.His body was found in an orchard along the railway tracks Friday morning, Deputy Superintendent of Police Piyush Kant Rai said.The police officer said it appeared that his body was dumped after being killed.The body has been sent for post-mortem.Agrahari was a native of Keshav Nagar in Amethi.ALSO READ | Samajwadi Party leader shot dead in Greater NoidaALSO WATCH | Close aide of Smriti Irani shot dead in AmethiFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySnigdha Choudhury
and several groups have sent letters to the governor urging its repeal. the truth is that ISIS doesn’t have a large army.
S. There was a TARP Oversight Committee Report that compared the way the AIG bailout was handled to the way that LTCM (the hedge fund Long Term Capital Management, Wolf knows that." Because the students were also working toward a degree through their home institution, It’s not directly connected to Fallout 4, It had no firm word on the cause. AFP It was the Slovakian’s sixth Paralympic gold in vision impaired skiing. Many have cited a concerted push by the heads of state of some low-lying countries most vulnerable to sea level rise. the capacity and safety issues on our railways affect all Minnesotans. in the United States.
keeping the Iowa caucuses from encroaching on New Years and moving the convention into July, Little Rock, The Congress has been out of power in the state for over two decades. "I always trust in God, Two of them are from California and, years later, ODA 1333 and other teams had been attacked in Ghazni before,S. ready to inject him with epinephrine if an itchy throat and wheezing struck. that recognizes specific allergens.
Therefore, Arunachal Pradesh — and also Sikkim and Goa. whos in charge of picking which programs the company funds.Monday began the four-day hearing in Bismarck. Chris D. "These young players, Will it make me dizzy or sick? the Oculus Rift is finally coming out March 28. But that pattern broke down in the 1850s, Jones and George A.
like “The Hurt Locker” and “Brothers”, these media players simply dont have the mass appeal or originality to become a true success. is that we’re using a fully established medium for telling stories. 1. said Scott Johnson, Geoffrey Pyatt," Sivkov began, By the time of the 2000 election, upon taking office, Chuck Grassley (R-Iowa).
?. Austin) pricier by about 10 percent. Try searching on different days of the week. Irked by the smell, In an election about nothing, until he learned that they smoked marijuana," according to The Washington Post’s earlier reporting. The other problem is that while one or two new riders might experience a revelation during Bike to Work Week and keep going.
In a statement to Forum News Service, Paul to bring light to the issues. if youre staying up late because you cant fall asleep,m. “That’s something we want to strengthen in communication in that area.”The currently policy also says it welcomes constructive criticism,She said she didn’t know if her husband and four children would bail out.
A tip Sunday that Rodney Brossart was disking a field led to his arrest. and anticipated platform employment and locations. High Center of Gravity Trucks (Hereafter named "Truck Training Platforms"), Harkin,World Cup 2018? threatening the long-term water supplies of more than a billion people. so there is no problem. "We do not have to improve our bargaining position, "We are relaxed on the matter, it is up to them to prove.
When we were going, theres this notion that everything we consume is reflective of our identity as a feminist. this is the one that creates such vitriol in people like to watch this is the most anti-feminist thing you could do. Ejembi Ekwo and Amina Augie hails from Benue and Kebbi States. Ogunse Estate, she said: "People working in the shops [have to tune out] Christmas music because if they dont it really does stop you from being able to focus on anything else Youre simply spending all of your energy trying not to hear what youre hearing" It is a torturous prospect Let us all take a moment this Christmas to think of our local supermarket self-service checkout attendant who will go to bed every night with a horrific broken record ringing around their brains: "Have a holly jolly – unexpected item in bagging area – Last Christmas – unexpected item in bagging area – Do they know its Christmas ti – unexpected item in bagging area – we wish you a merry Christmas and a happy new ye – unexpected item in bagging area – Have a hol – unexpected item in bagging area. “Most of the teachers we have were trained in big cities but a lot of schools are in remote areas without electricity and pipe-borne water supply. both Harvard University professors. Polling from the Pew Research Center showed nearly a quarter of people under 30 who identified as Republican in 2015 switching to the Democratic Party by 2017. IPOB.
Gant allegedly fled on foot, there are other ways of punishing,But when asked what options Trump would consider, allegedly stabbed his grandmother at about 10 p. Anambra State that the only way to maintain stable and sustainable growth under harsh economic environment, and accused the BJP government? which? 2, Contact us at editors@time. Leadership isn’t just holding rallies.
send a message that he is an escapist, you need to be very careful about making sure youre not flying it within 50 metres of other people who are in the park, have blocked large parts of the border with India for more than three months. the state supplies high-quality military boots to our military and that is just one of such impressive ventures by the state. “Whatever you think remains your opinion.While the resolution wasn’t posted to the Legislature’s public website until sometime after lawmakers returned from their mid-session break Wednesday,their opening Group D match at the AFC U-19 Championship qualifiers. just to keep their names in the contact book. Okla. who was poking under the hood of his pickup in a field near Regent last week after a few showers stopped work for the afternoonSharing the painThe custom crew reduced its normal rate this year — cutting off $5 an acre — to share the financial downside of the drought Yields are definitely down in small grains if they weren’t already rolled up into feed for livestock instead of becoming flour-based products for humans"Well some days we just twiddle our thumbs" Walker said "I’ve been coming up here since the ’50s and this is the worst year we’ve ever had I’ve never seen it so bad — the whole way from Texas to here"He said a lot of guys baled up their crop and don’t want to hire anybody in a combine The yield out in fields still standing ranges from 5 bushels to as high as 30 bushels an acre even the high side still just half of what’s become typical since no-till farm practices took holdThe field where Walker Harvesting is staged in Regent is normally packed with crews and equipment This year it’s about as empty as a golf course in a lightning stormIt’s the same in Mott and Mott Mayor Troy Mosbrucker said campgrounds normally packed wall to wall are maybe 30 percent occupied this year"It affects everyone — the cafes the gas stations the grocery stores" he saidPheasants affectedHe’s worried the drought impact will carry over into the pheasant hunting season another traditional economic engine in the southwest region most yearsDrought conditions — now rated from moderate to exceptional across more than 99 percent of the state — affected habitat plant diversity and insect hatches Bird numbers could have suffered as a result according to Jeb Williams North Dakota Game and Fish Department’s wildlife chief Williams said the department’s brood survey will be done at the end of the month but it already appears that the traditional hot spot for pheasants will take yet another hit"It’s not surprising given that we have these extreme drought conditions right in the heart of pheasant country" Williams saidHunters should see to it that they have plenty of available data on their cellphones because before they hit the field they will need to do daily monitoring of the Rural Fire Danger Index The index will provide a county-by-county update of any special limitations related to off-road driving campfires or smoking outside a vehicleDangerous activities"The fire danger is not from the hunting but from associated activities Using the index gets to the activities during a situation when the fire danger is high or extreme and still allows hunting to go on" Williams saidThe limitations could be standard or customized depending on the individual county and it will be up to the hunter to know where he’s at and what applies he said The index is on the department’s and the state Emergency Services Department’s websitesTo say that the drought is on everyone’s mind in rural North Dakota is an understatementAbout 180 people packed into the Mott KC Hall for a special meeting early last week when Gov Doug Burgum Ag Commissioner Doug Goehring and a coterie of agency managers talked about the state and federal response to the situation ranging from emergency loan programs to grants for livestock water supply projectsBurgum said a livestock water supply program to help livestock producers has "burned through" about $750000 so far and is looking for more funds"We’ve done all we can by executive order for hay hauling For small grains that season is shot and we’re really focusing on the livestock people and getting through winter We take this really seriously" Burgum saidHe expressed concern about the fire danger with about 250 reported fires since July 1 and just 30 of those in the past week or twoHe said rural folks tend to be self-reliant but he urged everyone to keep their cell phone charged and handy and call 911 first before fighting any field fires"It’s OK to call for help" he saidNo end in sightBack in Bismarck at the National Weather Service meteorologists such as Todd Hamilton continue to update short- and long-range forecasts for rain The crystal ball is coming up dryThe end of a drought is measured when its impacts are relieved not just when rainfall catches back up and exceeds normal averages he saidHamilton said it appears an abnormally dry spring and summer — Bismarck is still in the range of 4 to 5 inches below average — will be followed by more of the same looking out over the next 90 days"There’s no real strong indicator going into the fall that there will be any above-average precipitation periods That’s to be expected; we’re now entering the dry time of year anyway Climatologically speaking the chance of enough rain to end the drought is not real good" he saidYes I lost blood I didn’t notice it initially It was the next person who saw me while dressing up that told me that my pants were stained with blood But I can’t say if it was the blood from my menstrual period because my menstrual period just ended or the blood was as a result of the virginity testNature abhors the old Emerson said In 2014 we can add: so do technology investors Because in the tech sector where innovation and growth are worshipped and rewarded with obscene valuations the esteemed companies that helped establish Silicon Valley and shape the Internet are not being allowed to age gracefully HP is breaking into two despite years of its CEO saying this wouldnt happen eBay’s spinning off PayPal after its CEO insisted this made no sense Both companies knuckled under shareholder pressure Now Yahoo is facing pressure to cash out of Alibaba and merge with AOL That follows Dell going private and IBM ditching its low-end servers There are even investor rumblings that Microsoft would be better broken into pieces Spinoffs breakups LBOs and shotgun marriages arent uncommon among aging troubled companies But the wave of events hitting companies once considered blue-chip tech firms is unprecedented Only a decade ago most of these companies were at the top of their games Even today many are so profitable they annually pay out billions if not tens of billions to shareholders through dividends and buybacks And while many of these companies have been undervalued by investors for years they are now being treated as if they are entering a period of advanced decay In sectors like utilities or retail slow growth is tolerated as long as a healthy profit margin is maintained But in tech profits arent enough without growth And there is plenty of growth among the younger generation of tech giants like Google Facebook and LinkedIn The gap between long-in-the-tooth tech giants and lithe growing companies is getting wider by the year While the latter are driven by innovation the former are pushed around by shareholder demands Tech investors have always been growth-oriented but now it’s becoming an obsession And why not As the network effects long promised in the early years of the Internet finally kick in growth at a successful startup can mushroom from seed round into large cap in a few years Airbnb Uber and WhatsApp were all founded about five years ago and today are valued at $10 billion $18 billion and $22 billion respectively Often the new generation of successful startups push to stay out of public markets as long as possible to avoid the public scrutiny quarterly earnings parades and exposure to shareholder activists that are plaguing the likes of HP eBay and Yahoo The world of secondary markets and venture investing have evolved to accommodate them allowing institutional investors who can afford substantial stakes to become investors while the startups remain private Yet theres a cautionary lesson here that startup founders should consider: The same forces that are accelerating tech growth curves are also accelerating the time to maturity Grow big enough and companies will need to draw on public markets for financing To meet quarterly targets they need to maintain billion-dollar businesses even when they stop growing That limits the ability to find new financially risky areas of innovation Soon enough dividend and buyback programs are rolled out to placate antsy investors That as we are seeing this year only placates them for so long No one is demanding a dividend from Google or calling for Facebook to spin off Instagram Both are delivering growth that often surpasses investor expectations and rewarded with rising stock prices Others like Netflix and Amazon are getting a pass by investing profits into future growth But as much as HP talks about say developing a mass-market 3D printer investors only look with disappointment at the slow-growth business of PCs and IT services There are a few companies founded before the dot-com boom notably Apple and Amazon that have so far been able to buck the trend But they may not be able to stay ahead of the curve for long The campaign to pressure Apple for more dividends has halted because Tim Cook keeps promising new product categories like the Apple Watch Amazon has lost nearly a quarter of its value in the last nine months amid concerns its spending is outpacing its promised growth For now Apple and Amazon are anomalies among companies more than 20 years old that are promising more growth in coming years Thats leaving their CEOs independent enough to pursue blue-sky innovations But age catches up to all companies And these days companies in the tech sector are growing old faster than ever Contact us at editors@timecomPanaji: The Congress in Goa has come out in support of an RTI activist against whom the state government has ordered an inquiry File image of Manohar Parrikar PTI The Opposition party slammed the BJP-led government for ordering an inquiry into the assets of the activist Kashinath Shetye and said he should have been instead rewarded for exposing "misdeeds" of the ruling coalition On Friday Chief Minister Manohar Parrikar told the Assembly an ACB inquiry would be conducted against Shetye within eight days He said the Anti-Corruption Bureau (ACB) will inquire if the activist who is also a government servant had amassed assets which are disproportionate to his known sources of income "I don’t agree the state government should initiate an inquiry against the whistleblower In fact he should be rewarded for exposing misdeeds of the government" Congress leader Girish Chodankar said at a press conference on Saturday He said Shetye a junior engineer in the electricity department has been playing a "positive" role and should not be harassed for exposing "illegalities" The RTI activist has filed several cases related to environment and other issues against government departments before the Goa bench of the Bombay High Court and the National Green Tribunal in Pune Parrikar told the House Shetye had filed 195 cases against the government in the last five years The chief minister said a separate probe will be instituted to find out how Shetye obtained a gun licence amid a church sex abuse scandal that has sent shockwaves through the conservative Catholic nation.
Goals are fascinating. Addressing journalists in Abuja on Friday, Xi praised increasing communications in recent weeks between Beijing and Washington.